UND Life Sciences:
investigational research
for difficult-to-treat diseases.
Our lead program explores a lipid-based
approach (ARKA-101 / GLA) for Glioblastoma
(GBM). Information here is for education and partnership discussions.
If you're here as a patient or caregiver
We understand you may be seeking options for yourself or a loved one. This site provides educational information about our investigational research. ARKA-101 is not currently available as an approved treatment. We encourage you to discuss all treatment options with your medical team. If you'd like to learn more about our research or connect your physician with our team, please reach out through our contact form.
What we're developing
Our research focuses on lipid-based approaches for difficult-to-treat conditions.
Glioma / GBMARKA-101
Our lead program exploring a lipid-based approach for glioblastoma using local delivery.
Diabetic RetinopathySURYA-101
Investigational lipid mediator approach for diabetic eye disease, targeting VEGF and inflammation pathways.
Other Conditions
Exploring applications of our lipid-based platform in additional therapeutic areas.
Why GBM needs better options
Glioblastoma is one of the most challenging brain cancers, with limited treatment options available today.
Current standard-of-care approaches have remained largely unchanged for many years.
The blood-brain barrier limits the effectiveness of many systemic therapies.
Local delivery approaches may help address some of these challenges by targeting the tumor site directly.
How ARKA-101 is intended to be used
Administration concept (investigational)
Standard Surgery
Surgical removal of the tumor as part of standard care.
Reservoir Placement
A reservoir/catheter may be placed during surgery for local delivery.
Local Administration
Short course local administration concept (7–10 days).
Monitoring
Monitoring alongside standard care and follow-up.
ARKA-101 is investigational and not approved by the FDA or any regulatory authority. It is not available as an approved treatment option.
Evidence at a glance
- Laboratory studies have shown effects on tumor cell lines in controlled conditions.
- Animal model studies have demonstrated signals of tumor regression with local administration.
- Research has explored mechanisms related to lipid peroxidation and oxidative stress in tumor cells.
What this means
These findings provide a scientific rationale for further investigation.
What it doesn't mean
Preclinical results do not predict clinical outcomes in humans.
Development Roadmap
IND-enabling activities
GMP Manufacturing + Stability
In ProgressGLP Local Toxicity Study (10-day concept)
PlannedPK/TK During GLP
PlannedIND Submission
PlannedEarly Clinical Trials (Phase I/II concept)
FutureLearn more about our research
Request our information deck or contact us to discuss our GBM program, partnership opportunities, or to connect your medical team with our researchers.